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Issue 10, 2015
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Next-generation analysis of gene expression regulation – comparing the roles of synthesis and degradation

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Abstract

Technological advances now enable routine measurement of mRNA and protein abundances, and estimates of their rates of synthesis and degradation that inform on their values and the degree of change in response to stimuli. Importantly, more and more data on time-series experiments are emerging, e.g. of cells responding to stress, enabling first insights into a new dimension of gene expression regulation – its dynamics and how it allows for very different response signals across genes. This review discusses recently published methods and datasets, their impact on what we now know about the relationships between concentrations and synthesis rates of mRNAs and proteins in yeast and mammalian cells, their evolution, and new hypotheses on translation regulatory mechanisms generated by approaches that involve ribosome footprinting.

Graphical abstract: Next-generation analysis of gene expression regulation – comparing the roles of synthesis and degradation

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The article was received on 01 May 2015, accepted on 29 Jul 2015 and first published on 29 Jul 2015


Article type: Review Article
DOI: 10.1039/C5MB00310E
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Mol. BioSyst., 2015,11, 2680-2689

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    Next-generation analysis of gene expression regulation – comparing the roles of synthesis and degradation

    J. McManus, Z. Cheng and C. Vogel, Mol. BioSyst., 2015, 11, 2680
    DOI: 10.1039/C5MB00310E

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