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Issue 6, 2015
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Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem

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Abstract

A one-pot tandem enzyme reaction using galactose oxidase M3–5 and aldehyde oxidase PaoABC was used to convert hydroxymethylfurfural (HMF) to the pure bioplastics precursor FDCA in 74% isolated yield. A range of alcohols was also converted to carboxylic acids in high yield under mild conditions.

Graphical abstract: Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem

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Article information


Submitted
01 Apr 2015
Accepted
21 Apr 2015
First published
21 Apr 2015

Green Chem., 2015,17, 3271-3275
Article type
Communication
Author version available

Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem

S. M. McKenna, S. Leimkühler, S. Herter, N. J. Turner and A. J. Carnell, Green Chem., 2015, 17, 3271
DOI: 10.1039/C5GC00707K

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