Jump to main content
Jump to site search

Issue 5, 2015

Anti-atherogenic properties of date vs. pomegranate polyphenols: the benefits of the combination

Author affiliations

Abstract

Hydrolysable tannin polyphenols in pomegranate and phenolic acids in date fruit and seeds are potent antioxidants and anti-atherogenic agents, and thus, in the present study we investigated the possible benefits of combining them in vivo in atherosclerotic apolipoprotein E KO (E0) mice, compared with the individual fruit. In vitro studies revealed that the date seed extract contains more polyphenols than Amari or Hallawi date extracts, and possesses a most impressive free radical scavenging capacity. Similarly, pomegranate juice (PJ), punicalagin, punicalain, gallic acid, and urolithins A and B are very potent antioxidants. E0 mice consumed 0.5 μmol gallic acid equivalents (GAE) per mouse per day of PJ, Hallawi extract, date seed extract, or a combination for 3 weeks. Consumption of the combination was the most potent treatment, as it decreased serum cholesterol and triglyceride levels, and increased serum paraoxonase 1 (PON1) activity. Consumption of the combination also significantly reduced mouse peritoneal macrophage (MPM) oxidative stress, MPM cholesterol content, and MPM LDL uptake. Finally, the lipid peroxide content in the aortas of the mice significantly decreased, and the PON lactonase activity of the aortas increased after treatment with the combination. We thus conclude that consumption of pomegranate, together with date fruit and date seeds, has the most beneficial anti-atherogenic effects on E0 mice serum, macrophages, and aortas, probably due to their unique and varied structures.

Graphical abstract: Anti-atherogenic properties of date vs. pomegranate polyphenols: the benefits of the combination

Article information


Submitted
04 Nov 2014
Accepted
12 Mar 2015
First published
12 Mar 2015

Food Funct., 2015,6, 1496-1509
Article type
Paper
Author version available

Anti-atherogenic properties of date vs. pomegranate polyphenols: the benefits of the combination

M. Rosenblat, N. Volkova, H. Borochov-Neori, S. Judeinstein and M. Aviram, Food Funct., 2015, 6, 1496 DOI: 10.1039/C4FO00998C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements