Jump to main content
Jump to site search

Issue 1, 2015
Previous Article Next Article

Catalytic properties and biomedical applications of cerium oxide nanoparticles

Author affiliations

Abstract

Cerium oxide nanoparticles (nanoceria) have shown promise as catalytic antioxidants in the test tube, cell culture models and animal models of disease. However given the reactivity that is well established at the surface of these nanoparticles, the biological utilization of nanoceria as a therapeutic still poses many challenges. Moreover the form that these particles take in a biological environment, such as the changes that can occur due to a protein corona, are not well established. This review aims to summarize the existing literature on biological use of nanoceria, and to raise questions about what further study is needed to apply this interesting catalytic material to biomedical applications. These questions include: 1) How does preparation, exposure dose, route and experimental model influence the reported effects of nanoceria in animal studies? 2) What are the considerations to develop nanoceria as a therapeutic agent in regards to these parameters? 3) What biological targets of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are relevant to this targeting, and how do these properties also influence the safety of these nanomaterials?

Graphical abstract: Catalytic properties and biomedical applications of cerium oxide nanoparticles

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Aug 2014, accepted on 09 Nov 2014 and first published on 10 Nov 2014


Article type: Critical Review
DOI: 10.1039/C4EN00138A
Environ. Sci.: Nano, 2015,2, 33-53

  •   Request permissions

    Catalytic properties and biomedical applications of cerium oxide nanoparticles

    C. Walkey, S. Das, S. Seal, J. Erlichman, K. Heckman, L. Ghibelli, E. Traversa, J. F. McGinnis and W. T. Self, Environ. Sci.: Nano, 2015, 2, 33
    DOI: 10.1039/C4EN00138A

Search articles by author

Spotlight

Advertisements