Jump to main content
Jump to site search

Issue 6, 2015
Previous Article Next Article

Synthesis and characterisation of lanthanide-hydroporphyrin dyads

Author affiliations

Abstract

Fluorescence spectroscopy is in many ways the ideal tool for the interrogation of complex biological systems, as it is non-invasive, sensitive, and offers high spatiotemporal resolution. For biomedical imaging luminescent probes absorbing and emitting in the red-to-near infrared (NIR) region are best suited to maximise tissue penetration and minimise damage to cellular components. NIR-emitting lanthanides (Ln) sensitised with red-absorbing antennae are promising candidates for these applications, assuming the challenges of poor photophysical properties and tedious syntheses of the complexes are overcome. Chlorins are porphyrin-type tetrapyrroles with intense red absorption. Recently chlorins have been shown to sensitise Yb and Nd emission when incorporated into Ln-complexes. Here we expand on our previous work, and explore the effect of chlorin structure, metallation state, chlorin–Ln-complex linker length and mode of attachment on the properties of chlorin–Ln complexes. As chlorin absorption bands are ∼20 nm fwhm and readily tunable, a deeper understanding of structure–property relationships would enable the use of chlorin–Ln complexes in multicolour imaging using antenna-specific excitation. A detailed description of antenna and complex syntheses and photophysical characterisation is given. A number of challenges were identified, which will have to be addressed in future studies to enable multicolour imaging using the NIR-emitting lanthanides.

Graphical abstract: Synthesis and characterisation of lanthanide-hydroporphyrin dyads

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Aug 2014, accepted on 15 Oct 2014 and first published on 15 Oct 2014


Article type: Paper
DOI: 10.1039/C4DT02448F
Author version
available:
Download author version (PDF)
Dalton Trans., 2015,44, 2541-2553

  •   Request permissions

    Synthesis and characterisation of lanthanide-hydroporphyrin dyads

    R. Xiong, J. Andres, K. Scheffler and K. E. Borbas, Dalton Trans., 2015, 44, 2541
    DOI: 10.1039/C4DT02448F

Search articles by author

Spotlight

Advertisements