Jump to main content
Jump to site search

Issue 14, 2015
Previous Article Next Article

An overview of nanoparticles commonly used in fluorescent bioimaging

Author affiliations

Abstract

This article gives an overview of the various kinds of nanoparticles (NPs) that are widely used for purposes of fluorescent imaging, mainly of cells and tissues. Following an introduction and a discussion of merits of fluorescent NPs compared to molecular fluorophores, labels and probes, the article assesses the kinds and specific features of nanomaterials often used in bioimaging. These include fluorescently doped silicas and sol–gels, hydrophilic polymers (hydrogels), hydrophobic organic polymers, semiconducting polymer dots, quantum dots, carbon dots, other carbonaceous nanomaterials, upconversion NPs, noble metal NPs (mainly gold and silver), various other nanomaterials, and dendrimers. Another section covers coatings and methods for surface modification of NPs. Specific examples on the use of nanoparticles in (a) plain fluorescence imaging of cells, (b) targeted imaging, (c) imaging of chemical species, and (d) imaging of temperature are given next. A final section covers aspects of multimodal imaging (such as fluorescence/nmr), imaging combined with drug and gene delivery, or imaging combined with therapy or diagnosis. The electronic supplementary information (ESI) gives specific examples for materials and methods used in imaging, sensing, multimodal imaging and theranostics such as imaging combined with drug delivery or photodynamic therapy. The article contains 273 references in the main part, and 157 references in the ESI.

Graphical abstract: An overview of nanoparticles commonly used in fluorescent bioimaging

Back to tab navigation

Supplementary files

Article information


Submitted
16 Nov 2014
First published
26 Jan 2015

This article is Open Access

Chem. Soc. Rev., 2015,44, 4743-4768
Article type
Review Article
Author version available

An overview of nanoparticles commonly used in fluorescent bioimaging

O. S. Wolfbeis, Chem. Soc. Rev., 2015, 44, 4743 DOI: 10.1039/C4CS00392F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements