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Issue 19, 2015
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Small conjugate-based theranostic agents: an encouraging approach for cancer therapy

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Abstract

The advances in genomics, proteomics, and bioinformatics have directed the development of new anticancer agents to reduce drug abuse and increase safe and specific drug treatment. Theranostics, combining therapy and diagnosis, is an appealing approach for chemotherapy in medicine which exhibits improved biodistribution, selective cancer targeting ability, reduced toxicity, masked drug efficacy, and minimum side effects. The role of diagnosis tools in theranostics is to collect the information of the diseased state before and after specific treatment. Magnetic particle-, mesoporous silica-, various carbon allotrope-, and polymer nanoparticle-based theranostic systems are well accepted and clinically significant. Currently, small conjugate-based systems have received much attention for cancer treatment and diagnosis. The structural architecture of these systems is relatively simple, compact, biocompatible, and unidirectional. In this tutorial review, we summarize the latest developments on small conjugate based theranostic agents for tumor treatment and diagnosis using fluorescence and magnetic resonance imaging (MRI).

Graphical abstract: Small conjugate-based theranostic agents: an encouraging approach for cancer therapy

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Article information


Submitted
13 Mar 2015
First published
29 Jun 2015

Chem. Soc. Rev., 2015,44, 6670-6683
Article type
Tutorial Review

Small conjugate-based theranostic agents: an encouraging approach for cancer therapy

R. Kumar, W. S. Shin, K. Sunwoo, W. Y. Kim, S. Koo, S. Bhuniya and J. S. Kim, Chem. Soc. Rev., 2015, 44, 6670
DOI: 10.1039/C5CS00224A

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