Jump to main content
Jump to site search

Issue 17, 2015
Previous Article Next Article

Design strategies of fluorescent probes for selective detection among biothiols

Author affiliations

Abstract

Simple thiol derivatives, such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), play key roles in biological processes, and the fluorescent probes to detect such thiols in vivo selectively with high sensitivity and fast response times are critical for understanding their numerous functions. However, the similar structures and reactivities of these thiols pose considerable challenges to the development of such probes. This review focuses on various strategies for the design of fluorescent probes for the selective detection of biothiols. We classify the fluorescent probes for discrimination among biothiols according to reaction types between the probes and thiols such as cyclization with aldehydes, conjugate addition–cyclization with acrylates, native chemical ligation, and aromatic substitution-rearrangement.

Graphical abstract: Design strategies of fluorescent probes for selective detection among biothiols

Back to tab navigation

Publication details

The article was received on 17 Feb 2015 and first published on 01 Jun 2015


Article type: Review Article
DOI: 10.1039/C5CS00152H
Author version
available:
Download author version (PDF)
Chem. Soc. Rev., 2015,44, 6143-6160

  •   Request permissions

    Design strategies of fluorescent probes for selective detection among biothiols

    L. Niu, Y. Chen, H. Zheng, L. Wu, C. Tung and Q. Yang, Chem. Soc. Rev., 2015, 44, 6143
    DOI: 10.1039/C5CS00152H

Search articles by author

Spotlight

Advertisements