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Issue 14, 2015
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BODIPY-based probes for the fluorescence imaging of biomolecules in living cells

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Abstract

Fluorescence imaging techniques have been widely used to visualize biological molecules and phenomena. In particular, several studies on the development of small-molecule fluorescent probes have been carried out, because their fluorescence properties can be easily tuned by synthetic chemical modification. For this reason, various fluorescent probes have been developed for targeting biological components, such as proteins, peptides, amino acids, and ions, to the interior and exterior of cells. In this review, we cover advances in the development of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based fluorescent probes for biological studies over the past decade.

Graphical abstract: BODIPY-based probes for the fluorescence imaging of biomolecules in living cells

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Article information


Submitted
13 Jan 2015
First published
24 Mar 2015

Chem. Soc. Rev., 2015,44, 4953-4972
Article type
Review Article

BODIPY-based probes for the fluorescence imaging of biomolecules in living cells

T. Kowada, H. Maeda and K. Kikuchi, Chem. Soc. Rev., 2015, 44, 4953
DOI: 10.1039/C5CS00030K

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