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Issue 15, 2015
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Engineered biosynthesis of natural products in heterologous hosts

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Abstract

Natural products produced by microorganisms and plants are a major resource of antibacterial and anticancer drugs as well as industrially useful compounds. However, the native producers often suffer from low productivity and titers. Here we summarize the recent applications of heterologous biosynthesis for the production of several important classes of natural products such as terpenoids, flavonoids, alkaloids, and polyketides. In addition, we will discuss the new tools and strategies at multi-scale levels including gene, pathway, genome and community levels for highly efficient heterologous biosynthesis of natural products.

Graphical abstract: Engineered biosynthesis of natural products in heterologous hosts

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Publication details

The article was received on 12 Jan 2015 and first published on 11 May 2015


Article type: Review Article
DOI: 10.1039/C5CS00025D
Chem. Soc. Rev., 2015,44, 5265-5290

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    Engineered biosynthesis of natural products in heterologous hosts

    Y. Luo, B. Li, D. Liu, L. Zhang, Y. Chen, B. Jia, B. Zeng, H. Zhao and Y. Yuan, Chem. Soc. Rev., 2015, 44, 5265
    DOI: 10.1039/C5CS00025D

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