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Issue 13, 2015
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Protein recognition using synthetic small-molecular binders toward optical protein sensing in vitro and in live cells

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Abstract

Chemical sensing of amino acids, peptides, and proteins provides fruitful information to understand their biological functions, as well as to develop the medical and technological applications. To detect amino acids, peptides, and proteins in vitro and in vivo, vast kinds of chemical sensors including small synthetic binders/sensors, genetically-encoded fluorescent proteins and protein-based semisynthetic biosensors have been intensely investigated. This review deals with concepts, strategies, and applications of protein recognition and sensing using small synthetic binders/sensors, which are now actively studied but still in the early stage of investigation. The recognition strategies for peptides and proteins can be divided into three categories: (i) recognition of protein substructures, (ii) protein surface recognition, and (iii) protein sensing through protein–ligand interaction. Here, we overview representative examples of protein recognition and sensing, and discuss biological or diagnostic applications such as potent inhibitors/modulators of protein–protein interactions.

Graphical abstract: Protein recognition using synthetic small-molecular binders toward optical protein sensing in vitro and in live cells

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Article information


Submitted
12 Nov 2014
First published
25 Mar 2015

Chem. Soc. Rev., 2015,44, 4454-4471
Article type
Review Article

Protein recognition using synthetic small-molecular binders toward optical protein sensing in vitro and in live cells

R. Kubota and I. Hamachi, Chem. Soc. Rev., 2015, 44, 4454
DOI: 10.1039/C4CS00381K

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