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Issue 14, 2015
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Luminescent probes for the bioimaging of small anionic species in vitro and in vivo

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Abstract

The ability to spatiotemporally identify the formation of specific anionic species, or track changes in their concentration inside living systems, is of critical importance in deciphering their exact biological roles and effects. The development of probes (also called bioimaging agents and intracellular sensors) to achieve this goal has become a rapidly growing branch of supramolecular chemistry. In this critical review the challenges specific to the task are identified and for a select range of small anions of environmental and biological relevance (fluoride, chloride, iodide, cyanide, pyrophosphate, bicarbonate, hydrosulphide, peroxynitrite, hypochlorite and hypobromite) a comprehensive overview of the currently available in vitro and in vivo probes is provided.

Graphical abstract: Luminescent probes for the bioimaging of small anionic species in vitro and in vivo

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Article information


Submitted
03 Nov 2014
First published
12 Feb 2015

This article is Open Access

Chem. Soc. Rev., 2015,44, 4547-4595
Article type
Review Article
Author version available

Luminescent probes for the bioimaging of small anionic species in vitro and in vivo

T. D. Ashton, K. A. Jolliffe and F. M. Pfeffer, Chem. Soc. Rev., 2015, 44, 4547
DOI: 10.1039/C4CS00372A

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