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Issue 7, 2015
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Recent advances in Gd-chelate based bimodal optical/MRI contrast agents

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Abstract

Research on bimodal contrast agents in general and optical/MRI contrast agents in particular has attracted increased attention from the scientific community in recent years. Whereas optical contrast agents reveal pathologies at the cellular or sub-cellular level, MRI contrast agents generally report physiological differences at the level of tissues and organs. The complementary information obtained from these two techniques allows for a more precise diagnosis. Furthermore the emergence of near-infrared luminophores accommodates the simultaneous detection of optical and MRI signals. The current multitude and diversity in molecular architectures mirrors the ever increasing interest in the field. In this review the developments between 2010 and mid-2014 are highlighted.

Graphical abstract: Recent advances in Gd-chelate based bimodal optical/MRI contrast agents

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Submitted
09 Oct 2014
First published
27 Jan 2015

Chem. Soc. Rev., 2015,44, 1791-1806
Article type
Tutorial Review

Recent advances in Gd-chelate based bimodal optical/MRI contrast agents

P. Verwilst, S. Park, B. Yoon and J. S. Kim, Chem. Soc. Rev., 2015, 44, 1791
DOI: 10.1039/C4CS00336E

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