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Issue 7, 2015
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The chemistry and engineering of polymeric hydrogel adhesives for wound closure: a tutorial

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Abstract

The closure and repair of wounds after traumatic or surgical injury is of significant clinical and research importance. While sutures remain the common wound closure technique, they have many disadvantages. Consequently, polymeric hydrogel adhesives have emerged as essential materials for wound management and repair because of their tunable chemical and physical properties, which enable them to adhere or stick to tissues, possess sufficient mechanical strength to stay intact and be subsequently removed, provide complete wound occlusion, and act as a barrier to bacterial infection. Moreover, these materials absorb wound exudates and keep the wound moist for faster healing. This tutorial review summarizes the key chemical features that enabled the development and use of polymeric hydrogels as wound adhesives, sealants, and hemostats, their design requirements, synthetic routes, determination of properties, and the tests needed to evaluate their performances. This tutorial review is a reference and a starting point for scientists and clinicians working or interested in the field of wound management and, importantly, for the general audience who is interested in polymers for medical applications.

Graphical abstract: The chemistry and engineering of polymeric hydrogel adhesives for wound closure: a tutorial

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Publication details

The article was received on 02 Oct 2014 and first published on 04 Feb 2015


Article type: Tutorial Review
DOI: 10.1039/C4CS00332B
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Chem. Soc. Rev., 2015,44, 1820-1835

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    The chemistry and engineering of polymeric hydrogel adhesives for wound closure: a tutorial

    C. Ghobril and M. W. Grinstaff, Chem. Soc. Rev., 2015, 44, 1820
    DOI: 10.1039/C4CS00332B

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