Jump to main content
Jump to site search

Issue 9, 2015
Previous Article Next Article

Two-dimensional graphene analogues for biomedical applications

Author affiliations

Abstract

The increasing demand of clinical biomedicine and fast development of nanobiotechnology has substantially promoted the generation of a variety of organic/inorganic nanosystems for biomedical applications. Biocompatible two-dimensional (2D) graphene analogues (e.g., nanosheets of transition metal dichalcogenides, transition metal oxides, g-C3N4, Bi2Se3, BN, etc.), which are referred to as 2D-GAs, have emerged as a new unique family of nanomaterials that show unprecedented advantages and superior performances in biomedicine due to their unique compositional, structural and physicochemical features. In this review, we summarize the state-of-the-art progress of this dynamically developed material family with a particular focus on biomedical applications. After the introduction, the second section of the article summarizes a range of synthetic methods for new types of 2D-GAs as well as their surface functionalization. The subsequent section provides a snapshot on the use of these biocompatible 2D-GAs for a broad spectrum of biomedical applications, including therapeutic (photothermal/photodynamic therapy, chemotherapy and synergistic therapy), diagnostic (fluorescent/magnetic resonance/computed tomography/photoacoustic imaging) and theranostic (concurrent diagnostic imaging and therapy) applications, especially on oncology. In addition, we briefly present the biosensing applications of these 2D-GAs for the detection of biomacromolecules and their in vitro/in vivo biosafety evaluations. The last section summarizes some critical unresolved issues, possible challenges/obstacles and also proposes future perspectives related to the rational design and construction of 2D-GAs for biomedical engineering, which are believed to promote their clinical translations for benefiting the personalized medicine and human health.

Graphical abstract: Two-dimensional graphene analogues for biomedical applications

Back to tab navigation

Publication details

The article was received on 10 Sep 2014 and first published on 18 Dec 2014


Article type: Review Article
DOI: 10.1039/C4CS00300D
Chem. Soc. Rev., 2015,44, 2681-2701

  •   Request permissions

    Two-dimensional graphene analogues for biomedical applications

    Y. Chen, C. Tan, H. Zhang and L. Wang, Chem. Soc. Rev., 2015, 44, 2681
    DOI: 10.1039/C4CS00300D

Search articles by author

Spotlight

Advertisements