Jump to main content
Jump to site search

Issue 5, 2015
Previous Article Next Article

Concerning the crystal morphologies of the α and β polymorphs of p-aminobenzoic acid

Author affiliations

Abstract

The definition of crystal morphologies in polymorphic systems is a fundamental area of crystal engineering with implications for down-stream processing and formulation, which make morphological studies highly relevant. There are few recent examples of such detailed studies in the literature and here we address the case of p-aminobenzoic acid (PABA), focusing on its two polymorphic forms, α and β. Using a combination of modelling techniques to create predicted morphologies, we interpret these in the light of experimental data recorded on crystals grown from a range of polar solvents. Preliminary discussion of the intermolecular interactions involved in crystal growth of both forms, allow us to explore the enhanced morphological importance of the (002) face in α PABA and of (10[1 with combining macron]) and (0[1 with combining macron]1) faces for β PABA. It is suggested that desolvation plays a paramount role.

Graphical abstract: Concerning the crystal morphologies of the α and β polymorphs of p-aminobenzoic acid

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Sep 2014, accepted on 23 Oct 2014 and first published on 30 Oct 2014


Article type: Paper
DOI: 10.1039/C4CE01857E
CrystEngComm, 2015,17, 1015-1023

  •   Request permissions

    Concerning the crystal morphologies of the α and β polymorphs of p-aminobenzoic acid

    R. A. Sullivan and R. J. Davey, CrystEngComm, 2015, 17, 1015
    DOI: 10.1039/C4CE01857E

Search articles by author

Spotlight

Advertisements