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Issue 92, 2015
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NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro

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Abstract

The in vitro inter- and intra-cellular distribution of an isotopically labelled ruthenium(II)–arene (RAPTA) anti-metastatic compound in human ovarian cancer cells was imaged using nano-scale secondary ion mass spectrometry (NanoSIMS). Ultra-high resolution isotopic images of 13C, 15N, and Ru indicate that the phosphine ligand remains coordinated to the ruthenium(II) ion whereas the arene detaches. The complex localizes mainly on the membrane or at the interface between cells which correlates with its anti-metastatic effects.

Graphical abstract: NanoSIMS analysis of an isotopically labelled organometallic ruthenium(ii) drug to probe its distribution and state in vitro

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Publication details

The article was received on 19 Aug 2015, accepted on 23 Sep 2015 and first published on 23 Sep 2015


Article type: Communication
DOI: 10.1039/C5CC06983A
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Chem. Commun., 2015,51, 16486-16489
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    NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro

    R. F. S. Lee, S. Escrig, M. Croisier, S. Clerc-Rosset, G. W. Knott, A. Meibom, C. A. Davey, K. Johnsson and P. J. Dyson, Chem. Commun., 2015, 51, 16486
    DOI: 10.1039/C5CC06983A

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