Wavelength-dependent optoacoustic imaging probes for NMDA receptor visualisation

Neil Sim; Sven Gottschalk; Robert Pal; Martina Delbianco; Oleksiy Degtyaruk; Daniel Razansky; Gil G. Westmeyer; Vasilis Ntziachristos; David Parker; Anurag Mishra

doi:10.1039/C5CC06277B

Wavelength-dependent optoacoustic imaging probes for NMDA receptor visualisation†

Neil Sim,^a Sven Gottschalk,^b Robert Pal,^a Martina Delbianco,^a Oleksiy Degtyaruk,^b Daniel Razansky,^bc Gil G. Westmeyer,^bde Vasilis Ntziachristos,^bf David Parker*^a and Anurag Mishra*^b

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* Corresponding authors

^a Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK
E-mail: david.parker@durham.ac.uk

^b Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg 85764, Germany
E-mail: anurag.mishra@helmholtz-muenchen.de

^c School of Medicine, Technische Universität München (TUM), Munich 80333, Germany

^d Institute of Developmental Genetics, Helmholtz Zentrum, Neuherberg 85764, Germany

^e Department of Nuclear Medicine, Technische Universität München, Munich 80333, Germany

^f Chair for Biological Imaging, Technische Universität München, Munich 80333, Germany

Abstract

The cellular localisation and binding specificity of two NMDAR-targeted near-IR imaging probes has been examined by microscopy, followed by exemplification of MSOT to monitor simulated glutamate bursts in cellulo and a preliminary study in mice observing the signal in the brain.

Chemical Communications

Wavelength-dependent optoacoustic imaging probes for NMDA receptor visualisation†

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Wavelength-dependent optoacoustic imaging probes for NMDA receptor visualisation

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