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Issue 86, 2015
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MicroRNA detection based on analyte triggered nanoparticle localization on a tetrahedral DNA modified electrode followed by hybridization chain reaction dual amplification

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Abstract

We have constructed an ultrasensitive method for microRNA detection based on analyte triggered nanoparticle localization and hybridization chain reaction dual amplification. The limit of detection is 2 aM. Furthermore, the applicability of this method for microRNA assay in real samples is demonstrated by the analysis of cell lysates.

Graphical abstract: MicroRNA detection based on analyte triggered nanoparticle localization on a tetrahedral DNA modified electrode followed by hybridization chain reaction dual amplification

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Supplementary files

Article information


Submitted
03 Jul 2015
Accepted
09 Sep 2015
First published
09 Sep 2015

Chem. Commun., 2015,51, 15629-15632
Article type
Communication

MicroRNA detection based on analyte triggered nanoparticle localization on a tetrahedral DNA modified electrode followed by hybridization chain reaction dual amplification

P. Miao, Y. Tang and J. Yin, Chem. Commun., 2015, 51, 15629
DOI: 10.1039/C5CC05499K

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