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Issue 64, 2015
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Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

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Abstract

A heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced.

Graphical abstract: Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

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Supplementary files

Article information


Submitted
22 Jun 2015
Accepted
09 Jul 2015
First published
09 Jul 2015

This article is Open Access

Chem. Commun., 2015,51, 12867-12870
Article type
Communication
Author version available

Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

M. J. Rawling, T. E. Storr, W. A. Bawazir, S. J. Cully, W. Lewis, M. S. I. T. Makki, I. R. Strutt, G. Jones, D. Hamza and R. A. Stockman, Chem. Commun., 2015, 51, 12867
DOI: 10.1039/C5CC05070G

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