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Issue 64, 2015
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Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

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Abstract

A heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced.

Graphical abstract: Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

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Publication details

The article was received on 22 Jun 2015, accepted on 09 Jul 2015 and first published on 09 Jul 2015


Article type: Communication
DOI: 10.1039/C5CC05070G
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Chem. Commun., 2015,51, 12867-12870
  • Open access: Creative Commons BY license
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    Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

    M. J. Rawling, T. E. Storr, W. A. Bawazir, S. J. Cully, W. Lewis, M. S. I. T. Makki, I. R. Strutt, G. Jones, D. Hamza and R. A. Stockman, Chem. Commun., 2015, 51, 12867
    DOI: 10.1039/C5CC05070G

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