Recent trends in the development of vitamin B12 derivatives for medicinal applications

Abstract

This Feature Article highlights recent developments in the field of vitamin B₁₂ derivatives for medicinal applications. The following topics are emphasized: (1) the development of aquacorrinoids for cyanide detection and detoxification, (2) the use of vitamin B₁₂ conjugates and (3) antivitamins B₁₂ for therapy and diagnosis, and (4) the design of corrinoids as activators of soluble guanylyl cyclase (sGC).