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Issue 68, 2015
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Rh-catalyzed sequential oxidative C–H activation/annulation with geminal-substituted vinyl acetates to access isoquinolines

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Abstract

The concise synthesis of 3-substituted or non-C3-substituted isoquinolines through Rh-catalyzed sequential oxidative C–H activation/annulation with geminal-substituted vinyl acetates was developed with good functional group tolerance. The protocol was successfully applied to the total synthesis of the natural product papaverine.

Graphical abstract: Rh-catalyzed sequential oxidative C–H activation/annulation with geminal-substituted vinyl acetates to access isoquinolines

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Supplementary files

Article information


Submitted
08 Jun 2015
Accepted
13 Jul 2015
First published
14 Jul 2015

Chem. Commun., 2015,51, 13327-13329
Article type
Communication

Rh-catalyzed sequential oxidative C–H activation/annulation with geminal-substituted vinyl acetates to access isoquinolines

H. Chu, S. Sun, J. Yu and J. Cheng, Chem. Commun., 2015, 51, 13327
DOI: 10.1039/C5CC04708K

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