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Issue 64, 2015
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Catalytic meta-selective C–H functionalization to construct quaternary carbon centres

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Abstract

A catalytic meta-selective C–H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C–H functionalization proceeds through a radical process directed via a remote σ-activation.

Graphical abstract: Catalytic meta-selective C–H functionalization to construct quaternary carbon centres

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Publication details

The article was received on 12 May 2015, accepted on 06 Jul 2015 and first published on 06 Jul 2015


Article type: Communication
DOI: 10.1039/C5CC03951G
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Chem. Commun., 2015,51, 12807-12810
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    Catalytic meta-selective C–H functionalization to construct quaternary carbon centres

    A. J. Paterson, S. St John-Campbell, M. F. Mahon, N. J. Press and C. G. Frost, Chem. Commun., 2015, 51, 12807
    DOI: 10.1039/C5CC03951G

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