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Issue 63, 2015
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Synthesis of self-reporting polymeric nanoparticles for in situ monitoring of endocytic microenvironmental pH

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Abstract

The bis(pyrene) conjugated pH-sensitive polymers (P-BP) were synthesized and self-assembled into nanoparticles through hydrophobic interactions. The Nile red (NR) loaded P-BP nanoparticles showed red emission due to the FRET effect. The nanoparticles entered cells via endocytosis, and the microenvironmental pH in the endocytosis process was monitored in situ by the simultaneous dual-wavelength fluorescence changes.

Graphical abstract: Synthesis of self-reporting polymeric nanoparticles for in situ monitoring of endocytic microenvironmental pH

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The article was received on 06 May 2015, accepted on 30 Jun 2015 and first published on 30 Jun 2015


Article type: Communication
DOI: 10.1039/C5CC03752B
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Chem. Commun., 2015,51, 12609-12612

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    Synthesis of self-reporting polymeric nanoparticles for in situ monitoring of endocytic microenvironmental pH

    Z. Qiao, C. Hou, W. Zhao, D. Zhang, P. Yang, L. Wang and H. Wang, Chem. Commun., 2015, 51, 12609
    DOI: 10.1039/C5CC03752B

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