Issue 54, 2015

Chemoenzymatic one-pot synthesis in an aqueous medium: combination of metal-catalysed allylic alcohol isomerisation–asymmetric bioamination

Abstract

The ruthenium-catalysed isomerisation of allylic alcohols was coupled, for the first time, with asymmetric bioamination in a one-pot process in an aqueous medium. In the cases involving prochiral ketones, the ω-TA exhibited excellent enantioselectivity, identical to that observed in the single step. As a result, amines were obtained from allylic alcohols with high overall yields and excellent enantiomeric excesses.

Graphical abstract: Chemoenzymatic one-pot synthesis in an aqueous medium: combination of metal-catalysed allylic alcohol isomerisation–asymmetric bioamination

Supplementary files

Article information

Article type
Communication
Submitted
21 Apr 2015
Accepted
26 May 2015
First published
26 May 2015

Chem. Commun., 2015,51, 10937-10940

Chemoenzymatic one-pot synthesis in an aqueous medium: combination of metal-catalysed allylic alcohol isomerisation–asymmetric bioamination

N. Ríos-Lombardía, C. Vidal, M. Cocina, F. Morís, J. García-Álvarez and J. González-Sabín, Chem. Commun., 2015, 51, 10937 DOI: 10.1039/C5CC03298A

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