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Issue 59, 2015
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Conformational cooperativity between helical domains of differing geometry in oligoamide–oligourea foldamer chimeras

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Abstract

Linking together an oligourea and an oligoamide foldamer gives rise to a conformationally well-defined structure, despite the different hydrogen-bonding patterns in the two domains, provided the oligomers are ligated amide C terminus to urea N terminus. A powerful screw-sense preference induced at the N terminus of the resulting chimeric structure provides evidence for cooperative conformational interactions within the ‘block co-foldamer’.

Graphical abstract: Conformational cooperativity between helical domains of differing geometry in oligoamide–oligourea foldamer chimeras

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Article information


Submitted
10 Apr 2015
Accepted
05 Jun 2015
First published
05 Jun 2015

Chem. Commun., 2015,51, 11802-11805
Article type
Communication

Conformational cooperativity between helical domains of differing geometry in oligoamide–oligourea foldamer chimeras

J. Maury, B. A. F. Le Bailly, J. Raftery and J. Clayden, Chem. Commun., 2015, 51, 11802
DOI: 10.1039/C5CC02995C

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