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Issue 46, 2015
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Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol

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Abstract

A catalytic amidation method has been developed, employing 2,2,2-trifluoroethanol to facilitate condensation of unactivated esters and amines, enabling the synthesis of a range of amide products in good to excellent yields. Mechanistic studies indicate the reaction proceeds through a trifluoroethanol-derived active ester intermediate.

Graphical abstract: Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol

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Article information


Submitted
08 Apr 2015
Accepted
08 May 2015
First published
08 May 2015

Chem. Commun., 2015,51, 9495-9498
Article type
Communication
Author version available

Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol

N. Caldwell, C. Jamieson, I. Simpson and A. J. B. Watson, Chem. Commun., 2015, 51, 9495
DOI: 10.1039/C5CC02895G

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