Jump to main content
Jump to site search

Issue 34, 2015
Previous Article Next Article

Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach

Author affiliations

Abstract

A 241-membered cyanine-based library was constructed by the combinatorial chemistry strategy. Combined with high-throughput screening, we successfully discovered a novel fluorescent probe (CyC-M716) capable of identifying a subset of parallel G-quadruplexes with propeller loops stretching across three tetrad layers with high sensitivity and selectivity.

Graphical abstract: Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach

Back to tab navigation

Supplementary files

Article information


Submitted
23 Feb 2015
Accepted
23 Mar 2015
First published
24 Mar 2015

Chem. Commun., 2015,51, 7386-7389
Article type
Communication
Author version available

Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach

L. Zhang, J. C. Er, X. Li, J. J. Heng, A. Samanta, Y. Chang and C. K. Lee, Chem. Commun., 2015, 51, 7386
DOI: 10.1039/C5CC01601K

Social activity

Search articles by author

Spotlight

Advertisements