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Issue 35, 2015
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A general catalytic reaction sequence to access alkaloid-inspired indole polycycles

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Abstract

A catalytic two-step reaction sequence was developed to access a range of complex heterocyclic frameworks based on biorelevant indole/oxindole scaffolds. The reaction sequence includes catalytic Pictet–Spengler cyclization followed by Au(I) catalyzed intramolecular hydroamination of acetylenes. A related cascade polycyclization of a designed β-carboline embodying a 1,5-enyne group yields the analogues of the alkaloid harmicine.

Graphical abstract: A general catalytic reaction sequence to access alkaloid-inspired indole polycycles

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Publication details

The article was received on 20 Feb 2015, accepted on 20 Mar 2015 and first published on 20 Mar 2015


Article type: Communication
DOI: 10.1039/C5CC01555C
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Chem. Commun., 2015,51, 7536-7539

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    A general catalytic reaction sequence to access alkaloid-inspired indole polycycles

    A. Danda, K. Kumar and H. Waldmann, Chem. Commun., 2015, 51, 7536
    DOI: 10.1039/C5CC01555C

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