Issue 31, 2015

GSH- and pH-responsive drug delivery system constructed by water-soluble pillar[5]arene and lysine derivative for controllable drug release

Abstract

Novel GSH- and pH-responsive supramolecular vesicles constructed by an amphiphilic inclusion complex formed from water-soluble pillar[5]arene and lysine derivative have been successfully developed, which can efficiently encapsulate anticancer drug MTZ and show rapid MTZ-release in a simulated acidic tumor environment with high GSH concentration, and exhibit potent antitumor activity.

Graphical abstract: GSH- and pH-responsive drug delivery system constructed by water-soluble pillar[5]arene and lysine derivative for controllable drug release

Supplementary files

Article information

Article type
Communication
Submitted
14 Feb 2015
Accepted
09 Mar 2015
First published
11 Mar 2015

Chem. Commun., 2015,51, 6832-6835

GSH- and pH-responsive drug delivery system constructed by water-soluble pillar[5]arene and lysine derivative for controllable drug release

X. Wu, Y. Li, C. Lin, X. Hu and L. Wang, Chem. Commun., 2015, 51, 6832 DOI: 10.1039/C5CC01393C

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