Jump to main content
Jump to site search

Issue 61, 2015
Previous Article Next Article

Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers

Author affiliations

Abstract

A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0–7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.

Graphical abstract: Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers

Back to tab navigation

Supplementary files

Article information


Submitted
10 Feb 2015
Accepted
22 Jun 2015
First published
22 Jun 2015

Chem. Commun., 2015,51, 12258-12261
Article type
Communication
Author version available

Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers

S. Erbas-Cakmak, F. P. Cakmak, S. D. Topel, T. B. Uyar and E. U. Akkaya, Chem. Commun., 2015, 51, 12258
DOI: 10.1039/C5CC01261A

Social activity

Search articles by author

Spotlight

Advertisements