Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers†
A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0–7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.
- This article is part of the themed collection: Molecular Logic Gates and Information Processing