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Issue 15, 2015
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Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity

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Abstract

The effects of the repeated number (RN) of aminoethylene (AE) units in polyaspartamide side chains were investigated for polyion complex (PIC)-based siRNA delivery. Reduction of the apparent RN from 3 to 2 by thiourea introduction increased a protonatable amine fraction in AE units at endosomal pH, leading to the efficient endosomal escape of siRNA-loaded PICs.

Graphical abstract: Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity

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Publication details

The article was received on 10 Dec 2014, accepted on 09 Jan 2015 and first published on 09 Jan 2015


Article type: Communication
DOI: 10.1039/C4CC09859E
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Chem. Commun., 2015,51, 3158-3161

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    Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity

    H. Gao, H. Takemoto, Q. Chen, M. Naito, H. Uchida, X. Liu, K. Miyata and K. Kataoka, Chem. Commun., 2015, 51, 3158
    DOI: 10.1039/C4CC09859E

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