Issue 12, 2015

Novel lysosome targeted molecular transporter built on a guanidinium-poly-(propylene imine) hybrid dendron for efficient delivery of doxorubicin into cancer cells

Abstract

An efficient synthetic approach has been adopted to construct a new dendron-based octa-guanidine appended molecular transporter with a lysosomal targeted peptide–doxorubicin conjugate. The transporter alone (G8-PPI-FL) is found to be non-toxic, showed higher cellular uptake compared to Arg-8-mer and exhibited excellent selectivity towards lysosomes in cathepsin B expressing HeLa cells, while the Dox-conjugate showed significant cytotoxicity to cancer cells without affecting the non-cancerous cells.

Graphical abstract: Novel lysosome targeted molecular transporter built on a guanidinium-poly-(propylene imine) hybrid dendron for efficient delivery of doxorubicin into cancer cells

Supplementary files

Article information

Article type
Communication
Submitted
09 Dec 2014
Accepted
15 Dec 2014
First published
15 Dec 2014

Chem. Commun., 2015,51, 2403-2406

Novel lysosome targeted molecular transporter built on a guanidinium-poly-(propylene imine) hybrid dendron for efficient delivery of doxorubicin into cancer cells

J. B. Nair, S. Mohapatra, S. Ghosh and K. K. Maiti, Chem. Commun., 2015, 51, 2403 DOI: 10.1039/C4CC09829C

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