Jump to main content
Jump to site search

Issue 12, 2015
Previous Article Next Article

Novel lysosome targeted molecular transporter built on a guanidinium-poly-(propylene imine) hybrid dendron for efficient delivery of doxorubicin into cancer cells

Author affiliations

Abstract

An efficient synthetic approach has been adopted to construct a new dendron-based octa-guanidine appended molecular transporter with a lysosomal targeted peptide–doxorubicin conjugate. The transporter alone (G8-PPI-FL) is found to be non-toxic, showed higher cellular uptake compared to Arg-8-mer and exhibited excellent selectivity towards lysosomes in cathepsin B expressing HeLa cells, while the Dox-conjugate showed significant cytotoxicity to cancer cells without affecting the non-cancerous cells.

Graphical abstract: Novel lysosome targeted molecular transporter built on a guanidinium-poly-(propylene imine) hybrid dendron for efficient delivery of doxorubicin into cancer cells

Back to tab navigation

Supplementary files

Article information


Submitted
09 Dec 2014
Accepted
15 Dec 2014
First published
15 Dec 2014

Chem. Commun., 2015,51, 2403-2406
Article type
Communication

Novel lysosome targeted molecular transporter built on a guanidinium-poly-(propylene imine) hybrid dendron for efficient delivery of doxorubicin into cancer cells

J. B. Nair, S. Mohapatra, S. Ghosh and K. K. Maiti, Chem. Commun., 2015, 51, 2403
DOI: 10.1039/C4CC09829C

Social activity

Search articles by author

Spotlight

Advertisements