Jump to main content
Jump to site search

Issue 26, 2015
Previous Article Next Article

Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

Author affiliations

Abstract

Rapamycin-induced protein heterodimerization of FKBP12 and FRB is one of the most commonly employed switches to conditionally control biological processes. We developed an optically activated rapamycin dimer that does not induce FKBP12-FRB dimerization until exposed to light, and applied it to control kinase, protease, and recombinase function.

Graphical abstract: Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

Back to tab navigation

Supplementary files

Article information


Submitted
26 Nov 2014
Accepted
17 Feb 2015
First published
26 Feb 2015

Chem. Commun., 2015,51, 5702-5705
Article type
Communication

Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

K. A. Brown, Y. Zou, D. Shirvanyants, J. Zhang, S. Samanta, P. K. Mantravadi, N. V. Dokholyan and A. Deiters, Chem. Commun., 2015, 51, 5702
DOI: 10.1039/C4CC09442E

Social activity

Search articles by author

Spotlight

Advertisements