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Issue 26, 2015
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Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

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Abstract

Rapamycin-induced protein heterodimerization of FKBP12 and FRB is one of the most commonly employed switches to conditionally control biological processes. We developed an optically activated rapamycin dimer that does not induce FKBP12-FRB dimerization until exposed to light, and applied it to control kinase, protease, and recombinase function.

Graphical abstract: Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

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Publication details

The article was received on 26 Nov 2014, accepted on 17 Feb 2015 and first published on 26 Feb 2015


Article type: Communication
DOI: 10.1039/C4CC09442E
Citation: Chem. Commun., 2015,51, 5702-5705
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    Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

    K. A. Brown, Y. Zou, D. Shirvanyants, J. Zhang, S. Samanta, P. K. Mantravadi, N. V. Dokholyan and A. Deiters, Chem. Commun., 2015, 51, 5702
    DOI: 10.1039/C4CC09442E

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