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Issue 25, 2015
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β-(1-Azulenyl)-l-alanine – a functional probe for determination of pKa of histidine residues

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Abstract

β-(1-Azulenyl)-L-alanine (AzAla) can be incorporated into the influenza A virus M2 proton channel. AzAla's sensitivity to the protonation state of the nearby histidines and the lack of environmental fluorescence dependence allow for direct and straightforward determination of histidine pKa values in ion channels.

Graphical abstract: β-(1-Azulenyl)-l-alanine – a functional probe for determination of pKa of histidine residues

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Supplementary files

Article information


Submitted
02 Nov 2014
Accepted
20 Jan 2015
First published
23 Jan 2015

Chem. Commun., 2015,51, 5347-5350
Article type
Communication
Author version available

β-(1-Azulenyl)-L-alanine – a functional probe for determination of pKa of histidine residues

P. M. Gosavi, Y. S. Moroz and I. V. Korendovych, Chem. Commun., 2015, 51, 5347
DOI: 10.1039/C4CC08720H

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