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Issue 1, 2015
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Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

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Abstract

Heterocyclic arynes, or hetarynes, have been studied for over 100 years. However, challenges associated with observing these reactive species, as well as developing synthetically useful methods for their generation and trapping, have limited their use. This review provides a brief historical perspective on the field of hetarynes, in addition to a discussion of pyridyne and indolyne methodologies. Moreover, this review highlights the use of pyridynes, indolynes, and related strained intermediates in natural product synthesis.

Graphical abstract: Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

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Article information


Submitted
16 Aug 2014
Accepted
04 Sep 2014
First published
05 Sep 2014

Chem. Commun., 2015,51, 34-45
Article type
Feature Article

Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

A. E. Goetz, T. K. Shah and N. K. Garg, Chem. Commun., 2015, 51, 34
DOI: 10.1039/C4CC06445C

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