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Issue 6, 2015
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Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels

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Abstract

Selective inhibitors of voltage-activated K+ channels are needed for the treatment of multiple sclerosis. In this work it was discovered that porphyrins bearing 2–4 carbon alkyl ammonium side chains predominantly blocked the Kv1.1 current whilst Kv1.2 was susceptible to a porphyrin bearing polyamine side chains.

Graphical abstract: Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels

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Article information


Submitted
21 Jul 2014
Accepted
17 Nov 2014
First published
18 Nov 2014

Chem. Commun., 2015,51, 1066-1069
Article type
Communication
Author version available

Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels

D. Daly, A. Al-Sabi, G. K. Kinsella, K. Nolan and J. O. Dolly, Chem. Commun., 2015, 51, 1066
DOI: 10.1039/C4CC05639F

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