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Issue 11, 2015
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Hydrogels containing metallic glass sub-micron wires for regulating skeletal muscle cell behaviour

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Abstract

Hydrogels with tunable electrical and mechanical properties have a wide range of biological applications in tissue engineering, biosensing, and biorobotics. In this work, palladium-based metallic glass sub-micron wires (PdMGSMWs) were employed to enhance the conductivity and mechanical strength of gelatin methacryloyl (GelMA) gels. The values of electrical resistivity and stiffness of hybrid GelMA-PdMGSMW hydrogels were varied by the concentration of the sub-micron wires in the gels. Compared with pristine GelMA gels, hybrid GelMA-PdMGSMW gels were more efficient in regulating adhesion and spreading of C2C12 myoblasts. Formation, contractility, and metabolic activity of C2C12 myotubes in GelMA hydrogels also increased upon inclusion of the PdMGSMWs and applying electrical stimulation. The latter phenomenon is likely because of the electrical conductivity of hybrid GelMA gels.

Graphical abstract: Hydrogels containing metallic glass sub-micron wires for regulating skeletal muscle cell behaviour

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Publication details

The article was received on 30 Jun 2015, accepted on 20 Aug 2015 and first published on 07 Sep 2015


Article type: Paper
DOI: 10.1039/C5BM00215J
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Biomater. Sci., 2015,3, 1449-1458

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    Hydrogels containing metallic glass sub-micron wires for regulating skeletal muscle cell behaviour

    S. Ahadian, R. Banan Sadeghian, S. Yaginuma, J. Ramón-Azcón, Y. Nashimoto, X. Liang, H. Bae, K. Nakajima, H. Shiku, T. Matsue, K. S. Nakayama and A. Khademhosseini, Biomater. Sci., 2015, 3, 1449
    DOI: 10.1039/C5BM00215J

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