Hydrogels containing metallic glass sub-micron wires for regulating skeletal muscle cell behaviour

Samad Ahadian; Ramin Banan Sadeghian; Shin Yaginuma; Javier Ramón-Azcón; Yuji Nashimoto; Xiaobin Liang; Hojae Bae; Ken Nakajima; Hitoshi Shiku; Tomokazu Matsue; Koji S. Nakayama; Ali Khademhosseini

doi:10.1039/C5BM00215J

Hydrogels containing metallic glass sub-micron wires for regulating skeletal muscle cell behaviour†

Samad Ahadian,‡^a Ramin Banan Sadeghian,‡^a Shin Yaginuma,^a Javier Ramón-Azcón,^a Yuji Nashimoto,^b Xiaobin Liang,^a Hojae Bae,^c Ken Nakajima,^a Hitoshi Shiku,^b Tomokazu Matsue,^ab Koji S. Nakayama^a and Ali Khademhosseini*^acdefg

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* Corresponding authors

^a WPI-Advanced Institute for Materials Research, Tohoku University, Sendai 980-8577, Japan
E-mail: alik@rics.bwh.harvard.edu

^b Graduate School of Environmental Studies, Tohoku University, Sendai 980-8579, Japan

^c College of Animal Bioscience and Technology, Department of Bioindustrial Technologies, Konkuk University, Hwayang-dong, Kwangjin-gu, Seoul 143-701, Republic of Korea

^d Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA

^e Harvard-Massachusetts Institute of Technology, Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

^f Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA

^g Department of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21569, Saudi Arabia

Abstract

Hydrogels with tunable electrical and mechanical properties have a wide range of biological applications in tissue engineering, biosensing, and biorobotics. In this work, palladium-based metallic glass sub-micron wires (PdMGSMWs) were employed to enhance the conductivity and mechanical strength of gelatin methacryloyl (GelMA) gels. The values of electrical resistivity and stiffness of hybrid GelMA-PdMGSMW hydrogels were varied by the concentration of the sub-micron wires in the gels. Compared with pristine GelMA gels, hybrid GelMA-PdMGSMW gels were more efficient in regulating adhesion and spreading of C2C12 myoblasts. Formation, contractility, and metabolic activity of C2C12 myotubes in GelMA hydrogels also increased upon inclusion of the PdMGSMWs and applying electrical stimulation. The latter phenomenon is likely because of the electrical conductivity of hybrid GelMA gels.

Biomaterials Science

Hydrogels containing metallic glass sub-micron wires for regulating skeletal muscle cell behaviour†

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Hydrogels containing metallic glass sub-micron wires for regulating skeletal muscle cell behaviour

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