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Issue 2, 2015
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MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

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Abstract

Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.

Graphical abstract: MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

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Supplementary files

Article information


Submitted
12 Aug 2014
Accepted
09 Oct 2014
First published
28 Oct 2014

This article is Open Access

Biomater. Sci., 2015,3, 246-249
Article type
Communication
Author version available

MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

D. Kalafatovic, M. Nobis, N. Javid, P. W. J. M. Frederix, K. I. Anderson, B. R. Saunders and R. V. Ulijn, Biomater. Sci., 2015, 3, 246
DOI: 10.1039/C4BM00297K

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