Issue 2, 2015
From the journal:

Biomaterials Science

MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin†

Daniela Kalafatovic,a   Max Nobis,b   Nadeem Javid,a   Pim W. J. M. Frederix,a   Kurt I. Anderson,b   Brian R. Saundersc  and  Rein V. Ulijn*ade  

* Corresponding authors

a West CHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, UK

b The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK

c School of Materials, University of Manchester, Grosvenor Street, Manchester M1 7HS, UK

d Advanced Science Research Centre (ASRC), City University of New York, 85 St Nicholas Terrace, New York, NY 10031, USA
E-mail: Rein.Ulijn@asrc.cuny.edu

e Department of Chemistry and Biochemistry, City University of New York – Hunter College, 695 Park Ave., New York, NY 10065, USA

Abstract

Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.

Graphical abstract: MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

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Article information

DOI
https://doi.org/10.1039/C4BM00297K
Article type
Communication
Submitted
12 Aug 2014
Accepted
09 Oct 2014
First published
28 Oct 2014
This article is Open Access
Creative Commons BY license

Biomater. Sci., 2015,3, 246-249

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MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

D. Kalafatovic, M. Nobis, N. Javid, P. W. J. M. Frederix, K. I. Anderson, B. R. Saunders and R. V. Ulijn, Biomater. Sci., 2015, 3, 246 DOI: 10.1039/C4BM00297K

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