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Issue 9, 2015
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Lipophilicity study of fifteen fluoroquinolones by reversed-phase thin-layer chromatography

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Abstract

The lipophilicity of fifteen fluoroquinolones has been investigated. Reversed-phase thin layer chromatography with densitometric detection was applied to determine the RM0 factor. The RP-TLC investigations were performed in mixtures of organic modifier–water. The partition coefficients of examined fluoroquinolones were also calculated with computational programs. All the obtained data, from experimental methods and theoretical calculations, were compared and a suitable conclusion was reached. The received results demonstrate that the RP-TLC method may be the only reliable technique for fluoroquinolones in describing their lipophilic nature as well as the activity.

Graphical abstract: Lipophilicity study of fifteen fluoroquinolones by reversed-phase thin-layer chromatography

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Article information


Submitted
19 Sep 2014
Accepted
27 Mar 2015
First published
27 Mar 2015

Anal. Methods, 2015,7, 3841-3848
Article type
Paper

Lipophilicity study of fifteen fluoroquinolones by reversed-phase thin-layer chromatography

U. Hubicka, B. Żuromska-Witek, Ł. Komsta and J. Krzek, Anal. Methods, 2015, 7, 3841
DOI: 10.1039/C4AY02203C

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