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Issue 16, 2015
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Facile sonochemical synthesis of pH-responsive copper nanoclusters for selective and sensitive detection of Pb2+ in living cells

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Abstract

A one-pot sonochemical reaction of Cu(NO3)2 with glutathione (GSH), the latter functioning as a reducing agent and a stabilizing agent, rapidly affords Cu nanoclusters (NCs). The as-prepared GSH–CuNCs possess a small size (∼2.2 ± 0.2 nm), red luminescence with quantum yield (5.3%), and water-dispersibility. Moreover, the fluorescence of the as-prepared GSH–CuNCs is responsive to pH so that the intensity of fluorescence increases rapidly with decreasing pH from 9 to 4. Besides, the GSH–CuNCs would be aggregated by Pb2+ ions in aqueous solution which results in quenching of the fluorescence. Therefore, such GSH–CuNCs would be excellent candidates as fluorescent probes for the label-free detection of Pb2+ with the limit of detection at 1.0 nM. Importantly, CAL-27 cells are used as models to achieve potential application as probes for monitoring Pb2+ in living cells. Thus, these fluorescent CuNCs could work as an alternative to conventional fluorescent probes for biolabeling, sensing and other applications.

Graphical abstract: Facile sonochemical synthesis of pH-responsive copper nanoclusters for selective and sensitive detection of Pb2+ in living cells

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Supplementary files

Article information


Submitted
17 Apr 2015
Accepted
17 Jun 2015
First published
19 Jun 2015

Analyst, 2015,140, 5634-5639
Article type
Paper

Facile sonochemical synthesis of pH-responsive copper nanoclusters for selective and sensitive detection of Pb2+ in living cells

C. Wang, H. Cheng, Y. Huang, Z. Xu, H. Lin and C. Zhang, Analyst, 2015, 140, 5634
DOI: 10.1039/C5AN00741K

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