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Issue 16, 2015
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Relative quantitation of multi-antennary N-glycan classes: combining PGC-LC-ESI-MS with exoglycosidase digestion

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Abstract

In the search for N-glycan disease biomarkers current glycoanalytical methods may not be revealing a complete picture of precious samples, and we may be missing valuable structural information that fall outside analysis windows. We report a targeted strategy combining PGC-LC-ESI-MS with exoglycosidases to improve the relative quantitation of tri and tetra-antennary glycan classes.

Graphical abstract: Relative quantitation of multi-antennary N-glycan classes: combining PGC-LC-ESI-MS with exoglycosidase digestion

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Publication details

The article was received on 10 Apr 2015, accepted on 25 Jun 2015 and first published on 25 Jun 2015


Article type: Communication
DOI: 10.1039/C5AN00691K
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Analyst, 2015,140, 5444-5449

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    Relative quantitation of multi-antennary N-glycan classes: combining PGC-LC-ESI-MS with exoglycosidase digestion

    J. L. Abrahams, N. H. Packer and M. P. Campbell, Analyst, 2015, 140, 5444
    DOI: 10.1039/C5AN00691K

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