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Issue 8, 2015
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Coupling a solid phase microextraction (SPME) probe with ambient MS for rapid enrichment and detection of phosphopeptides in biological samples

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Abstract

In this study, we developed a probe-electrospray ionization method by coupling a SPME probe modified with nanosized TiO2 directly to nanoESI-MS for the phosphoproteome analysis, which demonstrated excellent selectivity and sensitivity for enrichment of phosphopeptides in complex biological samples.

Graphical abstract: Coupling a solid phase microextraction (SPME) probe with ambient MS for rapid enrichment and detection of phosphopeptides in biological samples

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Article information


Submitted
22 Nov 2014
Accepted
09 Feb 2015
First published
09 Feb 2015

Analyst, 2015,140, 2599-2602
Article type
Communication

Coupling a solid phase microextraction (SPME) probe with ambient MS for rapid enrichment and detection of phosphopeptides in biological samples

Y. Zhao, X. Gong, X. Si, Z. Wei, C. Yang, S. Zhang and X. Zhang, Analyst, 2015, 140, 2599
DOI: 10.1039/C4AN02156H

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