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Issue 11, 2015
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A review of the effects of FSCV and microdialysis measurements on dopamine release in the surrounding tissue

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Abstract

Microdialysis is commonly used in neuroscience to obtain information about the concentration of substances, including neurotransmitters such as dopamine (DA), in the extracellular space (ECS) of the brain. Measuring DA concentrations in the ECS with in vivo microdialysis and/or voltammetry is a mainstay of investigations into both normal and pathological function of central DA systems. Although both techniques are instrumental in understanding brain chemistry each has its shortcomings. The objective of this review is to characterize some of the tissue and DA differences associated with each technique in vivo. Much of this work will focus on immunohistochemical and microelectrode measurements of DA in the tissue next to the microdialysis probe and mitigating the response to the damage caused by probe implantation.

Graphical abstract: A review of the effects of FSCV and microdialysis measurements on dopamine release in the surrounding tissue

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Article information


Submitted
11 Nov 2014
Accepted
23 Mar 2015
First published
16 Apr 2015

Analyst, 2015,140, 3696-3708
Article type
Minireview
Author version available

A review of the effects of FSCV and microdialysis measurements on dopamine release in the surrounding tissue

A. Jaquins-Gerstl and A. C. Michael, Analyst, 2015, 140, 3696
DOI: 10.1039/C4AN02065K

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