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Issue 7, 2015
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Marker-free automated histopathological annotation of lung tumour subtypes by FTIR imaging

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Abstract

By integration of FTIR imaging and a novel trained random forest classifier, lung tumour classes and subtypes of adenocarcinoma are identified in fresh-frozen tissue slides automated and marker-free. The tissue slices are collected under standard operation procedures within our consortium and characterized by current gold standards in histopathology. In addition, meta data of the patients are taken. The improved standards on sample collection and characterization results in higher accuracy and reproducibility as compared to former studies and allows here for the first time the identification of adenocarcinoma subtypes by this approach. The differentiation of subtypes is especially important for prognosis and therapeutic decision.

Graphical abstract: Marker-free automated histopathological annotation of lung tumour subtypes by FTIR imaging

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Article information


Submitted
29 Oct 2014
Accepted
10 Dec 2014
First published
10 Dec 2014

This article is Open Access

Analyst, 2015,140, 2114-2120
Article type
Paper

Marker-free automated histopathological annotation of lung tumour subtypes by FTIR imaging

F. Großerueschkamp, A. Kallenbach-Thieltges, T. Behrens, T. Brüning, M. Altmayer, G. Stamatis, D. Theegarten and K. Gerwert, Analyst, 2015, 140, 2114
DOI: 10.1039/C4AN01978D

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