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Issue 4, 2015
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Carborane–β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

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Abstract

Supramolecular chemistry provides an attractive entry to generate dynamic and well-controlled bioactive surfaces. Novel host–guest systems are urgently needed to provide a broader affinity and applicability portfolio. A synthetic strategy to carborane–peptide bioconjugates was therefore developed to provide an entry to monovalent supramolecular functionalization of β-cyclodextrin coated surfaces. The β-cyclodextrin·carborane–cRGD surfaces are formed efficiently and with high affinity as demonstrated by IR-RAS, WCA, and QCM-D, compare favourable to existing bio-active host–guest surface assemblies, and display an efficient bioactivity, as illustrated by a strong functional effect of the supramolecular system on the cell adhesion and spreading properties. Cells seeded on the supramolecular surface displaying bioactive peptide epitopes exhibited a more elongated morphology, focal adhesions, and stronger cell adhesion compared to control surfaces. This highlights the macroscopic functionality of the novel supramolecular immobilization strategy.

Graphical abstract: Carborane–β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

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Supplementary files

Article information


Submitted
09 Sep 2014
Accepted
28 Oct 2014
First published
29 Oct 2014

This article is Open Access

J. Mater. Chem. B, 2015,3, 539-545
Article type
Paper
Author version available

Carborane–β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

P. Neirynck, J. Schimer, P. Jonkheijm, L.-G. Milroy, P. Cigler and L. Brunsveld, J. Mater. Chem. B, 2015, 3, 539
DOI: 10.1039/C4TB01489H

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