Issue 41, 2014

Multifunctional biodegradable mesoporous microspheres of Eu3+-doped amorphous calcium phosphate: microwave-assisted preparation, pH-sensitive drug release, and bioimaging application

Abstract

Biodegradable inorganic mesoporous materials hold promise for various biomedical applications such as drug/gene delivery, bioimaging, and photodynamic/photothermal and ultrasound therapy. Herein, multifunctional mesoporous microspheres of europium-doped amorphous calcium phosphate (Eu3+-doped ACP) have been prepared using a natural biomolecule adenosine triphosphate (ATP) by the rapid microwave-assisted solvothermal method. This method has advantages such as surfactant-free, rapid and energy-saving. The ATP molecule plays key roles as a phosphate source and a structure mediator. Furthermore, the Eu3+-doped ACP mesoporous microspheres exhibit advantages such as high specific surface area (from 253 to 315 m2 g−1), high biocompatibility, pH-responsive drug release, and in vitro/in vivo fluorescence imaging properties. The mechanism of pH-responsive drug release can be explained by the degradation of ACP mesoporous microspheres at low pH. The docetaxel-loaded Eu3+-doped ACP mesoporous microspheres showed good anticancer performance in vitro. The as-prepared Eu3+-doped ACP mesoporous microspheres are promising for applications in drug delivery, tissue engineering, bioimaging, etc.

Graphical abstract: Multifunctional biodegradable mesoporous microspheres of Eu3+-doped amorphous calcium phosphate: microwave-assisted preparation, pH-sensitive drug release, and bioimaging application

Supplementary files

Article information

Article type
Paper
Submitted
18 Jul 2014
Accepted
27 Aug 2014
First published
27 Aug 2014

J. Mater. Chem. B, 2014,2, 7132-7140

Author version available

Multifunctional biodegradable mesoporous microspheres of Eu3+-doped amorphous calcium phosphate: microwave-assisted preparation, pH-sensitive drug release, and bioimaging application

F. Chen, P. Huang, C. Qi, B. Lu, X. Zhao, C. Li, J. Wu, D. Cui and Y. Zhu, J. Mater. Chem. B, 2014, 2, 7132 DOI: 10.1039/C4TB01193G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements