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Issue 36, 2014
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Size dependent biological profiles of PEGylated gold nanorods

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Abstract

The perspective of introducing plasmonic particles for applications in biomedical optics is receiving much interest. However, their translation into clinical practices is delayed by various factors, which include a poor definition of their biological interactions. Here, we describe the preparation and the biological profiles of gold nanorods belonging to five different size classes with average effective radii between ∼5 and 20 nm and coated with polyethylene glycol (PEG). All these particles exhibit decent stability in the presence of representative proteins, low cytotoxicity and satisfactory compatibility with intravenous administration, in terms of their interference with blood tissue. However, the suspension begins to become unstable after a few days of exposure to blood proteins. Moreover, the cytotoxicity is a little worse for smaller particles, probably because their purification is more critical, while undesirable interactions with the mononuclear phagocyte system are minimal in the intermediate size range. Overall, these findings hold implications of practical relevance and suggest that PEGylated gold nanorods may be a versatile platform for a variety of biomedical applications.

Graphical abstract: Size dependent biological profiles of PEGylated gold nanorods

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Supplementary files

Article information


Submitted
18 Jun 2014
Accepted
17 Jul 2014
First published
18 Jul 2014

J. Mater. Chem. B, 2014,2, 6072-6080
Article type
Paper
Author version available

Size dependent biological profiles of PEGylated gold nanorods

F. Tatini, I. Landini, F. Scaletti, L. Massai, S. Centi, F. Ratto, S. Nobili, G. Romano, F. Fusi, L. Messori, E. Mini and R. Pini, J. Mater. Chem. B, 2014, 2, 6072
DOI: 10.1039/C4TB00991F

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