Jump to main content
Jump to site search

Issue 43, 2014
Previous Article Next Article

Biodistribution and clearance of aminoclay nanoparticles: implication for in vivo applicability as a tailor-made drug delivery carrier

Author affiliations

Abstract

3-Aminopropyl functionalized magnesium phyllosilicate (aminoclay) is a tailor-made organoclay material that has many biomedical applications. Defining the biodistribution and in vivo pharmacokinetics of aminoclay is essential to gauge the therapeutic potential of aminoclay. Therefore, the present study investigated the in vivo fate of aminoclay nanoparticles in a mouse model. Fluorescent Cy5.0-conjugated-aminoclay (Cy5.0-aminoclay) was synthesized for optical imaging and quantification in vivo and then its tissue distribution as well as elimination pathways was investigated in mice. After intravenous administration, fast tissue distribution of Cy5.0-aminoclay into various organs including the liver, kidney, lung, heart, and intestine was evident, as was the rapid clearance from each organ without any long-term accumulation. In addition, systemically administered nanoparticles were eliminated mainly from the urine and feces, where the nearly complete recovery of administered dose was achieved within 72 h. After oral administration, the biodistribution and pharmacokinetic studies indicated no intestinal absorption of Cy5.0-aminoclay. Consequently, about 90% of orally administered nanoparticles were eliminated via feces within 24 h. Taken all together, the present study highlights the low risk for long-term tissue accumulation of aminoclay particles, which may be desirable attributes for biomedical applications as a drug delivery carrier.

Graphical abstract: Biodistribution and clearance of aminoclay nanoparticles: implication for in vivo applicability as a tailor-made drug delivery carrier

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Jun 2014, accepted on 13 Sep 2014 and first published on 03 Oct 2014


Article type: Paper
DOI: 10.1039/C4TB00953C
J. Mater. Chem. B, 2014,2, 7567-7574

  •   Request permissions

    Biodistribution and clearance of aminoclay nanoparticles: implication for in vivo applicability as a tailor-made drug delivery carrier

    L. Yang, Y. Lee, M. I. Kim, H. G. Park, Y. S. Huh, Y. Shao and H. Han, J. Mater. Chem. B, 2014, 2, 7567
    DOI: 10.1039/C4TB00953C

Search articles by author

Spotlight

Advertisements