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Issue 24, 2014
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Active curcumin nanoparticles formed from a volatile microemulsion template

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Abstract

We report on the biological performance of organic nanoparticles formed by a simple method based on rapid solvent removal from a volatile microemulsion. The particular focus of the study was on testing the suitability of the method for substances soluble in partially water-miscible organic solvents as well as on evaluating the therapeutic activity of the resultant nanoparticles. Curcumin was employed as a model for hydrophobic drugs, and, as it is soluble in water-miscible organic solvents, it was successfully incorporated into a new cyclopentanone–water microemulsion system. During rapid solvent removal by spray-drying, the nanometric droplets of the microemulsion were converted into nanoparticles containing amorphous curcumin with an average size of 20.2 ± 3.4 nm, having a ζ potential of −36.2 ± 1.8 mV. These nanoparticles were dispersible in water and retained the high loading of the active substance. The therapeutic activity of the resulting nanoparticles was demonstrated in a pancreatic cancer cell line, PANC-1. The effective concentration for reducing the metabolic activity by 50% (EC50) was found to be 11.5 μM for nanoparticles compared with 19.5 μM for free curcumin.

Graphical abstract: Active curcumin nanoparticles formed from a volatile microemulsion template

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Article information


Submitted
18 Feb 2014
Accepted
17 Apr 2014
First published
19 May 2014

J. Mater. Chem. B, 2014,2, 3745-3752
Article type
Paper

Active curcumin nanoparticles formed from a volatile microemulsion template

K. Margulis, S. Srinivasan, M. J. Ware, H. D. Summers, B. Godin and S. Magdassi, J. Mater. Chem. B, 2014, 2, 3745
DOI: 10.1039/C4TB00267A

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